CD55 抗体
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北京 101111
Quick Overview for CD55 抗体 (ABIN5541173)
抗原
See all CD55 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody PD2 recognizes Pig complement decay accelerating factor (DAF), also designated as CD55.
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纯化方法
- Purified
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免疫原
- Pig DAF-Ig fusion protein.
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亚型
- IgG1
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应用备注
- Immuno Assays. Flow Cytometry (Ref.2). Western blot. Positive Control: Porcine platelet lysate. Typical starting working dilution: 1/50.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Buffer System: PBS Stabilizers: 0.1 % BSA
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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有效期
- 12 months
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- CD55 (Complement Decay-Accelerating Factor (CD55))
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别名
- cd55,daf
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背景
- Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Pig DAF (CD55) is a 45-52 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point.
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UniProt
- P08174
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途径
- Complement System, Regulation of Leukocyte Mediated Immunity
抗原
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