CTLA4 抗体 (AA 36-161)
Our Local Distributor
北京 101111
Quick Overview for CTLA4 抗体 (AA 36-161) (ABIN5541119)
抗原
See all CTLA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 36-161
-
特异性
- This antibody detects CTLA4 at aa 36-161.
-
纯化方法
- Protein-A affinity chromatography
-
免疫原
- Recombinant human CTLA4 (36-161aa) purified from E. coli
-
亚型
- IgG1
-
-
-
-
应用备注
- ELISA. Western blot: Recommended starting dilution is 1:3000. Immunocytochemistry / Immunoflourescence. Flow cytometry.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
-
有效期
- 12 months
-
-
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
-
别名
- cd152,ctla4
-
背景
- CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that downregulates the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Mutations in CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease and other autoimmune diseases.
-
UniProt
- P16410
-
途径
- Cancer Immune Checkpoints
抗原
-