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CTLA4 抗体 (AA 36-161)

This 小鼠 单克隆 anti-CTLA4 antibody (Clone AT4F2) specifically detects CTLA4 in WB, FACS, ICC, IF 和 EIA. The antibody is reactive with 人 samples.
产品编号 ABIN5541119
发货至: 中国
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Quick Overview for CTLA4 抗体 (AA 36-161) (ABIN5541119)

抗原

See all CTLA4 抗体
CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CTLA4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

克隆位点

AT4F2
  • 抗原表位

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    AA 36-161

    特异性

    This antibody detects CTLA4 at aa 36-161.

    纯化方法

    Protein-A affinity chromatography

    免疫原

    Recombinant human CTLA4 (36-161aa) purified from E. coli

    亚型

    IgG1
  • 应用备注

    ELISA. Western blot: Recommended starting dilution is 1:3000. Immunocytochemistry / Immunoflourescence. Flow cytometry.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

    有效期

    12 months
  • 抗原

    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

    别名

    cd152,ctla4

    背景

    CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein receptor that downregulates the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Mutations in CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, celiac disease and other autoimmune diseases.

    UniProt

    P16410

    途径

    Cancer Immune Checkpoints
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