VEGFC 抗体 (AA 101-221) (Biotin)
Quick Overview for VEGFC 抗体 (AA 101-221) (Biotin) (ABIN5540710)
抗原
See all VEGFC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-221
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特异性
- The unconjugated antibody will react with Rat VEGF-C and will cross-react with Human and Mouse VEGF-C proteins.
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纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Recombinant Rat VEGF-C native protein (Asp101-Ile221) derived from insect cells (Cat.-No DA3519X)
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亚型
- IgG
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应用备注
- ELISA: 1-5 μg/mL.
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限制
- 仅限研究用
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- VEGFC (Vascular Endothelial Growth Factor C (VEGFC))
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别名
- vegf-c,flt4-l
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背景
- VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
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UniProt
- O35757
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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