The unconjugated monoclonal antibody will detect native human TIE-2 /TEK in ELISA experiments and on the surface of different human cell types. Species: Human.
FACS analysis and cell sorting: ≤ 0.5 μg/mL in 100 μL.
限制
仅限研究用
状态
Liquid
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
有效期
12 months
抗原
TEK
(TEK Tyrosine Kinase, Endothelial (TEK))
别名
cd202b,tek
背景
TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.