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DKK2 抗体 (N-Term)

This anti-DKK2 antibody is a 兔 多克隆 antibody detecting DKK2 in WB 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN5538399
发货至: 中国

Quick Overview for DKK2 抗体 (N-Term) (ABIN5538399)

抗原

See all DKK2 抗体
DKK2 (Dickkopf 2 Homolog (DKK2))

适用

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  • 4
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  • 1
  • 1
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  • 1
人, 小鼠

宿主

  • 49
  • 5
  • 1

克隆类型

  • 50
  • 5
多克隆

标记

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  • 8
  • 4
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  • 1
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This DKK2 antibody is un-conjugated

应用范围

  • 43
  • 28
  • 24
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 8
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-62, N-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

    免疫原

    This DKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-62 amino acids from the N-terminal region of human DKK2.

    亚型

    Ig Fraction
  • 应用备注

    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    2 mg/mL

    缓冲液

    Supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原

    DKK2 (Dickkopf 2 Homolog (DKK2))

    别名

    DKK2

    背景

    The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.

    分子量

    28 kDa

    基因ID

    27123

    UniProt

    Q9UBU2

    途径

    WNT signaling
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