RUVBL1 抗体 (AA 247-280)
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北京 101111
Quick Overview for RUVBL1 抗体 (AA 247-280) (ABIN5537474)
抗原
See all RUVBL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 247-280
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
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免疫原
- This RUVBL1 (TIP49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-280 amino acids from the Central region of human RUVBL1 (TIP49).
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亚型
- Ig Fraction
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anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-240) antibody
RUVBL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-456) antibodyRUVBL1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3G4-1F8 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 101-400) antibodyRUVBL1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, ICC, DB 宿主: 小鼠 Monoclonal 2943C1a unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23096 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibodyRUVBL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 山羊 WB 宿主: 兔 Polyclonal unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (AA 1-456) antibodyRUVBL1 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal AT1D6 unconjugated
anti-RuvB-Like 1 (E. Coli) (RUVBL1) antibodyRUVBL1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.35 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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别名
- RUVBL1
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背景
- RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1 -CTNNB1 complex. High levels of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis.
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分子量
- 50 kDa
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基因ID
- 8607
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UniProt
- Q9Y265
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途径
- Telomere Maintenance
抗原
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