CDK8 抗体 (AA 245-272)
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Quick Overview for CDK8 抗体 (AA 245-272) (ABIN5532872)
抗原
See all CDK8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 245-272
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Cdk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the Central region of mouse Cdk8.
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亚型
- Ig Fraction
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anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 375-464) antibody
CDK8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 365-464) antibodyCDK8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (C-Term) antibodyCDK8 适用: 人, 小鼠 WB, ChIP-seq, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 21-392) antibodyCDK8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) antibodyCDK8 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 424-458), (C-Term) antibodyCDK8 适用: 人 WB 宿主: 兔 Polyclonal RB51053 unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- For WB starting dilution is: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
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别名
- Cdk8
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背景
- Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).
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分子量
- 53 kDa
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基因ID
- 264064
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UniProt
- Q8R3L8
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途径
- Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
抗原
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