NOS1 抗体 (C-Term)
(6 references)Quick Overview for NOS1 抗体 (C-Term) (ABIN5518781)
抗原
See all NOS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1402-1434, C-Term
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原理
- Anti-nNOS (neuronal)/NOS1 Antibody Picoband®
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序列
- VTLRTYEVTN RLRSESIAFI EESKKDTDEV FSS
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-nNOS (neuronal)/NOS1 Antibody Picoband® (ABIN5518781). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human nNOS(neuronal), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (C-Term) antibody
Verified NOS1 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 53-247) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 9-136) antibodyNOS1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 17-153) antibodyNOS1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2E11G6 unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (pSer852) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1213-1337) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 51-150) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 691-826) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (C-Term) antibodyNOS1 适用: 人 WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1418-1434), (C-Term) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1. "Entrez Gene: NOS1 Nitric oxide synthase 1 (neuronal)". 2. Shteyer, E., Edvardson, S., Wynia-Smith, S. L., Pierri, C. L., Zangen, T., Hashavya, S., Begin, M., Yaacov, B., Cinamon, Y., Koplewitz, B. Z., Vromen, A., Elpeleg, O., Smith, B. C. Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. Gastroenterology 148: 533-536, 2015. 3. Xu, W., Gorman, P., Sheer, D., Bates, G., Kishimoto, J., Lizhi, L., Emson, P. Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2-24.31 by fluorescent in situ hybridization. Cytogenet. Cell Genet. 64: 62-63, 1993. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation." in: International journal of molecular medicine, Vol. 41, Issue 2, pp. 649-658, (2018) (PubMed).
: "Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats." in: The Journal of reproduction and development, Vol. 61, Issue 3, pp. 219-27, (2015) (PubMed).
: "2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice." in: PLoS ONE, Vol. 7, Issue 12, pp. e50291, (2012) (PubMed).
: "Cell-specific expression and immunolocalization of nitric oxide synthase isoforms and the related nitric oxide/cyclic GMP signaling pathway in the ovaries of neonatal and immature rats." in: Journal of Zhejiang University. Science. B, Vol. 12, Issue 1, pp. 55-64, (2011) (PubMed).
: "Inhibition by brimonidine of forskolin-induced nitric oxide synthase expression in human ciliary bodies in vitro." in: Molecular vision, Vol. 13, pp. 493-6, (2007) (PubMed).
: "Distribution of constitutive nitric oxide synthase in the jejunum of adult rat." in: World journal of gastroenterology, Vol. 8, Issue 3, pp. 537-9, (2002) (PubMed).
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: "Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation." in: International journal of molecular medicine, Vol. 41, Issue 2, pp. 649-658, (2018) (PubMed).
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- NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
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别名
- NOS1
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背景
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Synonyms: Nitric oxide synthase, brain,1.14.13.39,Constitutive NOS,NC-NOS,N
Tissue Specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
Background: Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene. The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
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分子量
- 160 kDa
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基因ID
- 4842
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UniProt
- P29475
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途径
- Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
抗原
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