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IL-13 抗体 (AA 36-146)

This anti-IL-13 antibody is a 兔 多克隆 antibody detecting IL-13 in WB 和 IHC. Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN5518763
发货至: 中国

Quick Overview for IL-13 抗体 (AA 36-146) (ABIN5518763)

抗原

See all IL-13 (IL13) 抗体
IL-13 (IL13) (Interleukin 13 (IL13))

适用

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宿主

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克隆类型

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多克隆

标记

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This IL-13 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    AA 36-146

    原理

    Anti-IL13 Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-IL13 Antibody Picoband® (ABIN5518763). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E. coli-derived human IL13 recombinant protein (Position: P36-N146). Human IL13 shares 55.3% and 61.9% amino acid (aa) sequence identity with mouse and rat IL13, respectively.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Blackburn, M. R., Lee, C. G., Young, H. W. J., Zhu, Z., Chunn, J. L., Kang, M. J., Banerjee, S. K., Elias, J. A.Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. 2. Paul, W. E.Personal Communication.Bethesda, Md. 3/6/1993. 3. Punnonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N. J., Menon, S., Zurawski, G., de Waal Malefyt, R., de Vries, J. E.Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.Proc. Nat. Acad. Sci. 90: 3730-3734, 1993.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Wang, Cao, Liu, Zou, Li, Yang, Jiao: "Number 2 Feibi Recipe Reduces PM2.5-Induced Lung Injury in Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 3674145, (2018) (PubMed).

    Zhu, Li, Wu, Lu, You, Li, Li, Yang, Duan: "Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice." in: Toxicology research, Vol. 5, Issue 1, pp. 268-277, (2018) (PubMed).

    Li, Zhang, Qin, Bi, Liu, Li, Cai, Ma, Chan, Xie, Guan: "CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction." in: Oncotarget, Vol. 7, Issue 13, pp. 15525-38, (2017) (PubMed).

    Wang, Liang, Wang, Zhu, Gong, Zhang, Li, Xia: "Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice." in: PLoS neglected tropical diseases, Vol. 9, Issue 1, pp. e0003434, (2016) (PubMed).

    Long, Chen, Zhao, Rafaels, Mathias, Liang, Potee, Campbell, Zhang, Gao, Georas, Vercelli, Beaty, Ruczinski, Mathias, Barnes, Chen: "An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135360, (2016) (PubMed).

  • 抗原

    IL-13 (IL13) (Interleukin 13 (IL13))

    别名

    IL13

    背景

    Synonyms: Interleukin-13,IL-13,IL13,NC30,

    Tissue Specificity: Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

    Background: Interleukin 13 is a protein that in humans is encoded by the IL-13 gene. It is a kind of cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is an important mediator of allergic inflammation and disease. The IL-13 gene is mapped to 5q23-q31. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. Furthermore, this gene acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.

    分子量

    20 kDa

    基因ID

    3596

    UniProt

    P35225

    途径

    JAK/STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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