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Angiopoietin 2 抗体 (AA 180-283)

ANGPT2 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5518732
发货至: 中国
  • 抗原 See all Angiopoietin 2 (ANGPT2) 抗体
    Angiopoietin 2 (ANGPT2)
    抗原表位
    • 15
    • 10
    • 7
    • 5
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    • 2
    • 1
    • 1
    • 1
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    • 1
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    AA 180-283
    适用
    • 74
    • 37
    • 26
    • 4
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 76
    • 10
    • 4
    • 1
    • 1
    • 1
    克隆类型
    • 68
    • 25
    多克隆
    标记
    • 47
    • 10
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
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    This Angiopoietin 2 antibody is un-conjugated
    应用范围
    • 63
    • 31
    • 31
    • 13
    • 13
    • 11
    • 10
    • 10
    • 6
    • 6
    • 4
    • 4
    • 3
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    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with WB, IHC-P, ELISA in Human.
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with WB, IHC-P, ELISA in Human.
    Gene Name: angiopoietin 2
    Protein Name: Angiopoietin-2
    纯化方法
    Immunogen affinity purified.
    免疫原
    E. coli-derived human Angiopoietin-2 recombinant protein (Position: E180-D283). Human Angiopoietin-2 shares 75% and 77.9% amino acid (aa) sequence identity with mouse and rat Angiopoietin-2, respectively.
    亚型
    IgG
    Top Product
    Discover our top product ANGPT2 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Huang, Pan, Yu, Guo, Wang, Zhang, Wang, Gao: "Benefical therapeutic effect of Chinese Herbal Xinji'erkang formula on hypertension-induced renal injury in the 2-kidney-1-clip hypertensive rats." in: African journal of traditional, complementary, and alternative medicines : AJTCAM, Vol. 11, Issue 5, pp. 16-27, (2015) (PubMed).

    Bai, Li, Tian, Zhou: "Antiangiogenic treatment diminishes renal injury and dysfunction via regulation of local AKT in early experimental diabetes." in: PLoS ONE, Vol. 9, Issue 4, pp. e96117, (2014) (PubMed).

    Li, Fan, Song, Zhang, Chen, Li, Mi, Ma, Song, Tao, Li: "Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma." in: PLoS ONE, Vol. 8, Issue 9, pp. e75388, (2013) (PubMed).

  • 抗原
    Angiopoietin 2 (ANGPT2)
    别名
    ANGPT2 (ANGPT2 产品)
    别名
    AGPT2 antibody, ANG2 antibody, Agpt2 antibody, Ang-2 antibody, Ang2 antibody, ang2 antibody, angpt2 antibody, ANGIOPOIETIN-2 antibody, ANG-2 antibody, ANGPT2 antibody, Angrp antibody, Rnase5b antibody, ANG3 antibody, C11orf2 antibody, C11orf3 antibody, FFR antibody, angiopoietin 2 antibody, angiopoietin 2b antibody, angiogenin, ribonuclease A family, member 2 antibody, VPS51, GARP complex subunit antibody, ANGPT2 antibody, Angpt2 antibody, angpt2b antibody, Ang2 antibody, VPS51 antibody
    背景
    ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

    Synonyms: ANG 2 | ANG2 | ANG-2 | Angiopoietin 2 | Angiopoietin2 | Angiopoietin-2 | Angiopoietin2(ANG2) | Angiopoietin-2(ANG-2) | ANGP2 | ANGPT2 | O15123
    基因ID
    285
    UniProt
    O15123
    途径
    RTK signaling
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