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HMGCR 抗体 (C-Term)

HMGCR 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, Pig, 兔, Saccharomyces cerevisiae, Cow WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5516965
发货至: 中国
  • 抗原 See all HMGCR 抗体
    HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
    抗原表位
    • 16
    • 16
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    人, 大鼠, 小鼠, 犬, 豚鼠, 马, Pig, 兔, Saccharomyces cerevisiae, Cow
    宿主
    • 58
    • 3
    • 1
    克隆类型
    • 48
    • 14
    多克隆
    标记
    • 20
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HMGCR antibody is un-conjugated
    应用范围
    • 48
    • 29
    • 26
    • 26
    • 13
    • 8
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    PSIEIGTVGG GTNLLPQQAC LQMLGVQGAC KDNPGENARQ LARIVCGTVM
    预测反应
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 100%
    产品特性
    This is a rabbit polyclonal antibody against HMDH. It was validated on Western Blot.
    纯化方法
    Affinity purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human HMGCR
    Top Product
    Discover our top product HMGCR Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
    别名
    HMGCR (HMGCR 产品)
    别名
    HMGR antibody, LDLCQ3 antibody, hmg-coa-r antibody, HMG-CoAR antibody, Red antibody, 3H3M antibody, BcDNA:LD15354 antibody, CG10367 antibody, Clb antibody, DmHMG-CoAr antibody, Dmel\\CG10367 antibody, HMGCR antibody, HMGCR_Dm antibody, HMGCoAR antibody, HMGCoARr antibody, HMGCoAr antibody, HmG-CoAR antibody, Hmg antibody, bro1 antibody, bs32f05.y1 antibody, clb antibody, hmgc antibody, hmgcr antibody, hmgrc antibody, l(3)01152 antibody, l(3)04684 antibody, hmgcr2 antibody, im:6912716 antibody, zgc:110746 antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, HMG Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase b antibody, HMGCR antibody, hmgcr.L antibody, Hmgcr antibody, hmgcrb antibody
    背景
    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Alias Symbols: HMGCR,

    Protein Interaction Partner: UBC, INSIG1, AMFR, INSIG2, AUP1, DCUN1D1, ERLIN2, RNF139, VCP, STARD13, ARHGAP1, PRKACA, HMGCR,

    Protein Size: 888
    基因ID
    3156
    UniProt
    P04035
    途径
    AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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