HMGCR 抗体 (C-Term)
Quick Overview for HMGCR 抗体 (C-Term) (ABIN5516965)
抗原
See all HMGCR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- PSIEIGTVGG GTNLLPQQAC LQMLGVQGAC KDNPGENARQ LARIVCGTVM
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 100%
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产品特性
- This is a rabbit polyclonal antibody against HMDH. It was validated on Western Blot.
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human HMGCR
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anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 629-888) antibody
HMGCR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 638-887) antibodyHMGCR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 588-887) antibodyHMGCR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (N-Term) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 251-350) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (Internal Region) antibodyVerified HMGCR 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-835) antibodyHMGCR 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR 适用: 人, 大鼠, 小鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
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别名
- HMGCR
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背景
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HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HMGCR,
Protein Interaction Partner: UBC, INSIG1, AMFR, INSIG2, AUP1, DCUN1D1, ERLIN2, RNF139, VCP, STARD13, ARHGAP1, PRKACA, HMGCR,
Protein Size: 888 -
基因ID
- 3156
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UniProt
- P04035
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途径
- AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
抗原
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