DAXX 抗体 (N-Term)
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北京 101111
Quick Overview for DAXX 抗体 (N-Term) (ABIN5515954)
抗原
See all DAXX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- KLNLAPAATT SNEPSGNNPP THLSLDPTNA ENTASQSPRT RGSRRQIQRL
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产品特性
- This is a rabbit polyclonal antibody against DAXX. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAXX
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- DAXX (Death-Domain Associated Protein (DAXX))
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别名
- DAXX
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背景
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This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Alias Symbols: Name=DAXX
Protein Interaction Partner: FAM9B, SSX2IP, SUMO1, UBE2I, UBC, GOLGA2, CARD9, PBXIP1, CDCA7L, NECAB2, RASSF1, PML, MDM2, H3F3A, DNMT1, TP53, ATRX, CARM1, PRMT1, WHSC1L1, CUL3, SPOP, HIPK2, PDCD4, DNMT3A, USP7, UBB, RELB, DAXX, CREB1, CBS, ATM, HIST1H4F, HIST1H3C, TRAF3, HIST4H4, BTBD
Protein Size: 740 -
基因ID
- 1616
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NCBI登录号
- NP_001341
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UniProt
- Q9UER7
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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