ALIX 抗体 (C-Term)
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北京 101111
Quick Overview for ALIX 抗体 (C-Term) (ABIN5514748)
抗原
See all ALIX (PDCD6IP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS
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产品特性
- This is a rabbit polyclonal antibody against PDC6I. It was validated on Western Blot.
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDC6I
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
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别名
- PDC6I
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背景
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This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Alias Symbols: PDCD6IP, AIP1, ALIX, KIAA1375,
Protein Interaction Partner: UBI4, CEP55, UBC, SUMO2, nef, EZH2, IPO9, UBA6, MCTS1, AHCYL1, EZR, UBA1, MAPK1, CHMP4B, gag, UBD, BAG3, RNF11, KEAP1, VCAM1, SH3GL1, CHMP4C, TNIP2, ITGA4, CXCR1, GRB2, HOXA1, PEF1, VPS4B, ABCC1, GPI, PDCD6, F2R, CUL3, ALG2, PTK2B, TUBB, SIRT7, SH3KBP1, C
Protein Size: 868 -
基因ID
- 10015
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NCBI登录号
- NP_037506
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UniProt
- Q8WUM4
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途径
- p53 Pathway, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation
抗原
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