ANAPC5 抗体 (Middle Region)
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北京 101111
Quick Overview for ANAPC5 抗体 (Middle Region) (ABIN5514501)
抗原
See all ANAPC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- HSLLHYFDRL ILTGAESKSN GEEGYGRSLR YAALNLAALH CRFGHYTSPP
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against ANAPC5. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of Human ANAPC5
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))
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别名
- ANAPC5
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背景
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This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
Alias Symbols: ANAPC5, APC5,
Protein Interaction Partner: ANAPC2, UBE2S, UBC, ANAPC4, HECW2, LATS2, PHF8, SOX2, PTEN, CDC27, BACH1, TRIM33, ANAPC7, ANAPC15, CDH1, CDC20, PAXIP1, MDC1, TP53BP1, NOTCH1, ANAPC1, ANAPC13, CDC16, CDC23, FBXO5, USP37, CUL4A, SH3KBP1, E2F1, SMARCAD1, MAPK6, Gm9174, Anapc5, Mad2l1, Anap
Protein Size: 219 -
基因ID
- 51433
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途径
- M Phase
抗原
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