Vangl1 抗体 (AA 148-400)
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北京 101111
Quick Overview for Vangl1 抗体 (AA 148-400) (ABIN5027627)
抗原
See all Vangl1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 148-400
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.
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亚型
- IgG
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anti-Vang-Like 1 (Vangl1) (AA 275-524) antibody
Vangl1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (Internal Region) antibodyVangl1 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (AA 1-524) antibodyVangl1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (Internal Region) antibodyVangl1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (AA 1-524) antibodyVangl1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (N-Term) antibodyVangl1 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Vang-Like 1 (Vangl1) (AA 229-476) antibodyVangl1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 2-4 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Vangl1 (Vang-Like 1 (Vangl1))
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别名
- Vang like-1
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背景
- Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.
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分子量
- 62 kDa
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基因ID
- 81839
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UniProt
- Q8TAA9
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途径
- WNT signaling
抗原
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