TLR10 抗体 (AA 100-369)
Quick Overview for TLR10 抗体 (AA 100-369) (ABIN5027569)
抗原
See all TLR10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-369
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纯化方法
- Protein G Chromatography
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免疫原
- A partial length recombinant TLR10 protein (amino acids 100-369) was used as the immunogen for this antibody.
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亚型
- IgG2a kappa
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anti-Toll-Like Receptor 10 (TLR10) (AA 1-811) antibody
TLR10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A11 unconjugated
anti-Toll-Like Receptor 10 (TLR10) (AA 20-250) antibodyTLR10 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 10 (TLR10) (AA 81-111) antibodyTLR10 适用: 人 WB, IHC, ICC 宿主: 山羊 Polyclonal unconjugated
anti-Toll-Like Receptor 10 (TLR10) (AA 617-784) antibodyTLR10 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 2-4 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- TLR10 (Toll-Like Receptor 10 (TLR10))
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别名
- TLR10
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背景
- TLR10 (Toll-Like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and biological function. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection leading to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1Beta, specifically after exposure to TLR2 ligands. TLR10 is in a locus that also contains TLR1 and TLR6, two receptors known to function as coreceptors for TLR2. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. Expression of TLR10 can be induced in B cells, dendritic cells, eosinophils, and neutrophils, as well as on nonimmune cells, such as trophoblasts.
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分子量
- 116 kDa
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基因ID
- 81793
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UniProt
- Q9BXR5
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途径
- TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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