PD-L1 抗体 (AA 13-224)
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- 抗原 See all PD-L1 抗体
- PD-L1 (CD274 (PD-L1))
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抗原表位
- AA 13-224
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PD-L1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
- 纯化方法
- Protein G Chromatography
- 免疫原
- A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.
- 克隆位点
- ABM5F25
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product PD-L1 Primary Antibody
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- 应用备注
- FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL, IHC: 5-10 μg/mL
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS containing 0.05 % BSA, PH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin." in: PLoS ONE, Vol. 16, Issue 1, pp. e0245581, (2021) (PubMed).
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Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin." in: PLoS ONE, Vol. 16, Issue 1, pp. e0245581, (2021) (PubMed).
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- 抗原
- PD-L1 (CD274 (PD-L1))
- 别名
- PDL-1 (PD-L1 产品)
- 别名
- B7-H antibody, B7H1 antibody, PD-L1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, A530045L16Rik antibody, B7h1 antibody, Pdcd1l1 antibody, Pdcd1lg1 antibody, Pdl1 antibody, RGD1566211 antibody, CD274 molecule antibody, CD274 antigen antibody, programmed cell death 1 ligand 2 antibody, CD274 antibody, Cd274 antibody, PDCD1LG2 antibody
- 背景
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
- 分子量
- 44 kDa
- 基因ID
- 29126
- UniProt
- Q9NZQ7
- 途径
- Cancer Immune Checkpoints
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