DNMT1 抗体 (AA 128-429)
Quick Overview for DNMT1 抗体 (AA 128-429) (ABIN5027162)
抗原
See all DNMT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 128-429
-
交叉反应
- 小鼠
-
纯化方法
- Protein G Chromatography
-
免疫原
- A partial length recombinant DNMT1 protein (amino acids 128-429) was used as the immunogen for this antibody.
-
亚型
- IgG1 kappa
-
-
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibodyDNMT1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibodyKO Validated DNMT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1448-1594) antibodyDNMT1 适用: 人, 猴 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 7C11A2 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 21-120) antibodyDNMT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibodyDNMT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibodyDNMT1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 2D10G8 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 881-914) antibodyDNMT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51461 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibodyDNMT1 适用: 人 WB, IHC, IP, ChIP 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibodyDNMT1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D5G2 unconjugated
-
-
应用备注
- WB: 2-4 μg/mL, IHC: 5 μg/mL, FACS: 0.5 μg/10^6 cells
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS containing 0.05 % BSA, PH 7.4
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
-
-
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
-
别名
- Dnmt1
-
背景
- Dnmt1(DNA (cytosine-5-)-methyltransferase 1 ) is one of the most abundant DNA methyltransferase in mammalian tissues, where it associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. Dnmt1 comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2). The C-terminal domains of mammalian Dnmts contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. Dnmt1 maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity. The molecules interacting with Dnmt1, including RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules are involved in chromatin organization, DNA repair, cell cycle regulation, and apoptosis.
-
分子量
- 183
-
基因ID
- 1786
-
UniProt
- P26358
-
途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
-
