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Cyclin D1 抗体 (AA 108-322)

This 小鼠 单克隆 antibody specifically detects Cyclin D1 in IHC. It exhibits reactivity toward 人.
产品编号 ABIN5027124
发货至: 中国
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Quick Overview for Cyclin D1 抗体 (AA 108-322) (ABIN5027124)

抗原

See all Cyclin D1 (CCND1) 抗体
Cyclin D1 (CCND1)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Cyclin D1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)

克隆位点

ABM47F5
  • 抗原表位

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    AA 108-322

    纯化方法

    Protein G Chromatography

    免疫原

    A partial length recombinant Cyclin D1 protein (amino acids 108-322) was used as the immunogen for this antibody.

    亚型

    IgG2a kappa
  • 应用备注

    IHC: 5-10 μg/mL

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS containing 0.05 % BSA, PH 7.4

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原

    Cyclin D1 (CCND1)

    别名

    Cyclin D1

    背景

    Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. It regulate cell cycle transition from G1 phase to S phase It is a well-established human oncogene which is frequently amplified or overexpressed in cancers (25409185). Cyclin D1b is one of two proteins translated from Cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Low Cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues was significantly lower than that in well-differentiated tissues (25120779). Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma.

    基因ID

    23582

    UniProt

    O95273

    途径

    PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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