CD33 抗体 (AA 28-320)
Quick Overview for CD33 抗体 (AA 28-320) (ABIN5027091)
抗原
See all CD33 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 28-320
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纯化方法
- Protein G Chromatography
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免疫原
- A partial length recombinant CD33 protein (amino acids 28-320) was used as the immunogen for this antibody.
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亚型
- IgG2a kappa
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应用备注
- WB: 2-4 μg/mL, IHC: 5 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- CD33
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别名
- CD33
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背景
- CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
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分子量
- 39 kDa
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基因ID
- 945
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UniProt
- P20138
抗原
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