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MME 抗体 (AA 282-496)

Name: MME 抗体 (AA 282-496)
SKU: ABIN5027077
Availability: OutOfStock

MME 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal ABM4A52 unconjugated

Immunohistochemistry (IHC) image for anti-Membrane Metallo-Endopeptidase (MME) (AA 282-496) antibody (ABIN5027077) (MME 抗体 (AA 282-496))

IHC

1 image

产品编号 ABIN5027077

发货至: 中国

Datasheet as PDF

抗原 See all MME 抗体

MME (Membrane Metallo-Endopeptidase (MME))
抗原表位
16

14

9

8

8

7

7

7

6

6

5

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 282-496
适用
200

57

50

3

2

2

2

2

2

1

1

1

1
人
宿主
109

96

2
小鼠
Compatible Secondaries
克隆类型
105

101

2
单克隆
标记
103

19

17

13

9

6

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MME antibody is un-conjugated
应用范围
130

92

77

67

35

27

20

20

13

13

10

8

5

5

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

纯化方法

Protein G Chromatography

免疫原

A partial length recombinant CD10 protein (amino acids 282-496) was used as the immunogen for this antibody.

克隆位点

ABM4A52

亚型

IgG2b kappa

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anti-Membrane Metallo-Endopeptidase (MME) (AA 52-750) antibody
MME 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 0.5-1 μg/mL, IHC: 5-10 μg/mL

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

PBS containing 0.05 % BSA, PH 7.4

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
抗原

MME (Membrane Metallo-Endopeptidase (MME))

别名

CD10 (MME 产品)

别名

CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody

物质类

Chemical

背景

CD10, also known as membrane metalloendopeptidase, neutral endopeptidase, neprilysin and common acute lymphoblastic leukaemia antigen (CALLA), is a zinc-dependent metalloendoprotease that cleaves signaling peptides. It is widely expressed in various normal tissues and in epithelial, stromal or both components of various malignancies. CD10 is a marker for intestinal epithelial brush border. It is also present in normal bile ducts and gallbladder epithelia but is absent in cholangiocarcinomas. It is con-sidered as the prototype of this family of membrane-bound, zinc-dependent endopeptidases, which regulate the physiological action of various peptides by lowering their extracellular concentration available for receptor binding. CD10 is also known to be an amyloid b-peptide (Ab) degrading enzyme. Polymorphisms in the CD10 gene increase the risk for Alzheimer disease. Outside the nervous system, it is present on the surface of neutrophils and regulates their activation by degradation of in ammatory peptides.

分子量

97 kDa

基因ID

4311

UniProt

P08473

途径

RTK signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration