GCET2 抗体
Quick Overview for GCET2 抗体 (ABIN5026982)
抗原
See all GCET2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G Chromatography
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免疫原
- A full length human HGAL protein was used as the immunogen for this antibody
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亚型
- IgG1 kappa
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anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibody
GCET2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 31-130) antibodyGCET2 适用: 小鼠 ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibodyGCET2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) antibodyGCET2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) antibodyGCET2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (AA 1-178) antibodyGCET2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Germinal Center Expressed Transcript 2 (GCET2) (C-Term) antibodyGCET2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC: 5 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- GCET2 (Germinal Center Expressed Transcript 2 (GCET2))
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别名
- HGAL
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背景
- Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
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基因ID
- 257144
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UniProt
- Q8N6F7
抗原
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