UCMA 抗体 (C-Term)
This anti-UCMA antibody is a 兔 多克隆 antibody detecting UCMA in WB 和 EIA. Suitable for 人 和 小鼠.
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Quick Overview for UCMA 抗体 (C-Term) (ABIN501098)
抗原
See all UCMA 抗体
UCMA
(Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This UCMA antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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特异性
- This antibody detects UCMA.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography
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免疫原
- UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 2.5 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))
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别名
- UCMA
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背景
- UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.Synonyms: C10orf49, Unique cartilage matrix-associated protein
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基因ID
- 221044
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NCBI登录号
- NP_660357
抗原
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