RNF216 抗体 (N-Term)
This anti-RNF216 antibody is a 兔 多克隆 antibody detecting RNF216 in WB, IHC (p) 和 EIA. Suitable for 人 和 小鼠.
Quick Overview for RNF216 抗体 (N-Term) (ABIN501040)
抗原
See all RNF216 抗体
RNF216
(Ring Finger Protein 216 (RNF216))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This RNF216 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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特异性
- This antibody detects RNF216 / TRIAD3.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Ion exchange chromatography
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免疫原
- TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
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亚型
- IgG
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anti-Ring Finger Protein 216 (RNF216) (C-Term) antibody
RNF216 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- RNF216 (Ring Finger Protein 216 (RNF216))
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别名
- RNF216
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背景
- Activation of NF-kappaB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9, this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B
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基因ID
- 54476
抗原
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