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TLR6 抗体 (N-Term)

This anti-TLR6 antibody is a 兔 多克隆 antibody detecting TLR6 in WB, IF 和 EIA. Suitable for 人 和 小鼠.
产品编号 ABIN500958
发货至: 中国

Quick Overview for TLR6 抗体 (N-Term) (ABIN500958)

抗原

See all TLR6 抗体
TLR6 (Toll-Like Receptor 6 (TLR6))

适用

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人, 小鼠

宿主

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  • 1

克隆类型

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  • 17
多克隆

标记

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This TLR6 antibody is un-conjugated

应用范围

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  • 1
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Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • 抗原表位

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    • 2
    • 2
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    • 1
    • 1
    • 1
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    • 1
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    N-Term

    特异性

    This antibody detects CD286 / TLR6 at N-term.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse

    纯化方法

    Peptide affinity chromatography

    免疫原

    TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    TLR6 (Toll-Like Receptor 6 (TLR6))

    别名

    CD286 / TLR6

    背景

    Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69 % sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6).Synonyms: Toll-like receptor 6

    基因ID

    10333

    NCBI登录号

    NP_006059

    途径

    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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