RAD17 抗体 (AA 101-230) (AbBy Fluor® 680)
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- 抗原 See all RAD17 抗体
- RAD17
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抗原表位
- AA 101-230
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RAD17 antibody is conjugated to AbBy Fluor® 680
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应用范围
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Rad17
- 亚型
- IgG
- Top Product
- Discover our top product RAD17 Primary Antibody
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- RAD17
- 别名
- Rad17 (RAD17 产品)
- 背景
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Synonyms: RFC, CCYC, Cell cycle checkpoint protein, Cell cycle checkpoint protein RAD17, HRAD 17, hRad17, R24L, Rad 17, Rad 24, RAD1 S. pombe homolog, RAD17, RAD17 homolog, Rad17 like protein, RAD17_HUMAN, RAD17Sp, Rad24, RF C activator 1 homolog, RF C/activator 1 homolog, RF-C/activator 1 homolog.
Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
- 基因ID
- 5884
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