PKM2 抗体 (AA 255-350) (AbBy Fluor® 680)
Quick Overview for PKM2 抗体 (AA 255-350) (AbBy Fluor® 680) (ABIN5008903)
抗原
See all PKM2 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 255-350
- 
                                            交叉反应
- 人, 小鼠, 大鼠
- 
                                            预测反应
- Cow,Pig,Horse,Rabbit
- 
                                            纯化方法
- Purified by Protein A.
- 
                                            免疫原
- KLH conjugated synthetic peptide derived from mouse Pyruvate kinase PKM
- 
                                            亚型
- IgG
 
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    - 
                                            应用备注
- 
                        FCM 1:20-100
 IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
- 
                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
- 
                                            浓度
- 1 μg/μL
- 
                                            缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 
                                            储存液
- ProClin
- 
                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 
                                            储存条件
- -20 °C
- 
                                            储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 
                                            有效期
- 12 months
 
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    - PKM2 (Pyruvate Kinase M2 (PKM2))
- 
                                            别名
- PKM2
- 
                                            背景
- 
                        Synonyms: PK3, TCB, OIP3, PKM2, CTHBP, THBP1, HEL-S-3, Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, Tumor M2-PK, p58, PKM, PK2, Pyruvate kinase PKLR, Pyruvate kinase 1, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase. Background: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. 
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                                            基因ID
- 5315, 5313
- 
                                            UniProt
- P14618, P30613
- 
                                            途径
- Warburg Effect
 抗原
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