SKIL 抗体 (N-Term)
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Quick Overview for SKIL 抗体 (N-Term) (ABIN500786)
抗原
See all SKIL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects SKIL / SnoN. It will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinita chromatography
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免疫原
- SnoN antibody was raised against a 16 amino acid peptide from near the amino terminus of human SnoN.
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亚型
- IgG
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anti-SKI-Like Oncogene (SKIL) (AA 307-684) antibody
SKIL 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 359-579) antibodySKIL 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 236-313) antibodySKIL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 301-400) antibodySKIL 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 420-684) antibodySKIL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (C-Term) antibodySKIL 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 307-684) antibodySKIL 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-SKI-Like Oncogene (SKIL) (AA 542-591) antibodySKIL 适用: 人, 大鼠, Cow, 豚鼠, Pig, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- SKIL (SKI-Like Oncogene (SKIL))
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别名
- SKIL / SnoN
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背景
- TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN.Synonyms: SNO, Ski-like protein, Ski-related novel protein N, Ski-related oncogene, Ski-related protein, SnoA, Snol
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基因ID
- 6498
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NCBI登录号
- NP_005405
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UniProt
- P12757
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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