RUSC1 抗体 (C-Term)
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Quick Overview for RUSC1 抗体 (C-Term) (ABIN500648)
抗原
See all RUSC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects NESCA.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- RUSC1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human RUSC1.
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亚型
- IgG
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anti-RUN and SH3 Domain Containing 1 (RUSC1) (AA 1-320) antibody
RUSC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RUN and SH3 Domain Containing 1 (RUSC1) (AA 231-433) antibodyRUSC1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RUN and SH3 Domain Containing 1 (RUSC1) (AA 1-433) antibodyRUSC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- RUSC1 (RUN and SH3 Domain Containing 1 (RUSC1))
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别名
- NESCA
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背景
- RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30 % amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IkappaB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kappaB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappaB activation pathway.Synonyms: RUN and SH3 domain-containing protein 1, RUSC1
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基因ID
- 23623
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NCBI登录号
- NP_001098673
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UniProt
- Q9BVN2
抗原
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