NPAS3 抗体 (N-Term)
This anti-NPAS3 antibody is a 兔 多克隆 antibody detecting NPAS3 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for NPAS3 抗体 (N-Term) (ABIN500379)
抗原
See all NPAS3 抗体
NPAS3
(Neuronal PAS Domain Protein 3 (NPAS3))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This NPAS3 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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特异性
- This antibody detects NPAS3 / MOP6 at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Peptide affinity chromatography
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免疫原
- NPAS3 antibody was raised against a 28 amino acid peptide from near the amino terminus of human NPAS3.
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亚型
- IgG
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anti-Neuronal PAS Domain Protein 3 (NPAS3) (Middle Region) antibody
NPAS3 适用: 人, 小鼠, 大鼠, 斑马鱼, 兔, 马, 豚鼠, 山羊, 犬, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
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别名
- NPAS3 / MOP6
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背景
- Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.Synonyms: Basic-helix-loop-helix-PAS protein MOP6, Member of PAS protein 6, Neuronal PAS domain-containing protein 3, Neuronal PAS3
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基因ID
- 64067
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UniProt
- Q8IXF0
抗原
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