MAP3K14 抗体 (C-Term)
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Quick Overview for MAP3K14 抗体 (C-Term) (ABIN500347)
抗原
See all MAP3K14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 931-947, C-Term
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特异性
- This antibody detects MAP3K14 at C-term.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- DEAE purified
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免疫原
- NIK antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK.
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亚型
- IgG
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应用备注
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ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))
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别名
- MAP3K14
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背景
- Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha and CD95 was identified recently and designated NIK (for NF-kappaB inducing kinase) . NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta). Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.Synonyms: Mitogen-activated protein kinase kinase kinase 14, NF-kappa beta-inducing kinase, Serine/threonine-protein kinase NIK
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基因ID
- 9020
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UniProt
- Q99558
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途径
- NF-kappaB Signaling, TCR Signaling
抗原
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