LY96 抗体 (Center)
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北京 101111
Quick Overview for LY96 抗体 (Center) (ABIN500262)
抗原
See all LY96 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Ion exchange chromatography
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免疫原
- MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 0.5 to 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- LY96 (Lymphocyte Antigen 96 (LY96))
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别名
- MD-2
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背景
- MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2, e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2
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NCBI登录号
- NP_056179
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UniProt
- Q9Y6Y9
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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