MADD 抗体 (C-Term)
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Quick Overview for MADD 抗体 (C-Term) (ABIN500216)
抗原
See all MADD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects MADD at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- DEAE purified
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免疫原
- MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD.
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亚型
- IgG
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anti-MAP-Kinase Activating Death Domain (MADD) antibody
KD Validated MADD 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB110 unconjugated Recombinant Antibody
anti-MAP-Kinase Activating Death Domain (MADD) antibodyMADD 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibodyMADD 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (C-Term) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (Internal Region) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP-Kinase Activating Death Domain (MADD) (AA 751-800) antibodyMADD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 1: 250 - 1: 500 dilution, 200 to 220 kDa bands should be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- MADD (MAP-Kinase Activating Death Domain (MADD))
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别名
- MADD
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背景
- MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98 % identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94 % overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87 % identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.Synonyms: DENN, IG20, MAP kinase-activating death domain protein, RAB3GEP, Rab3 GDP/GTP exchange factor
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基因ID
- 8567
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UniProt
- Q8WXG6
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途径
- Caspase Cascade in Apoptosis
抗原
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