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Desmin 抗体 (pThr17) (AbBy Fluor® 750)

This anti-Desmin antibody is a 兔 多克隆 antibody detecting Desmin in WB. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN5001193
发货至: 中国

Quick Overview for Desmin 抗体 (pThr17) (AbBy Fluor® 750) (ABIN5001193)

抗原

See all Desmin (DES) 抗体
Desmin (DES)

适用

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人, 大鼠, 小鼠

宿主

  • 132
  • 68
  • 2

克隆类型

  • 114
  • 88
  • 1
多克隆

标记

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This Desmin antibody is conjugated to AbBy Fluor® 750

应用范围

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Western Blotting (WB)
  • 抗原表位

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    • 2
    • 1
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    • 1
    • 1
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    pThr17

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Cow,Chicken

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr17

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Desmin (DES)

    别名

    Desmin

    背景

    Synonyms: Desmin phospho Thr17, Desmin phospho Thr17, CMD1I, CSM1, CSM2, DES, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865, DESM_HUMAN

    Background: filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin are useful in identification of tumours of myogenic origin.

    基因ID

    1674
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