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CD82 抗体 (C-Term)

This anti-CD82 antibody is a 兔 多克隆 antibody detecting CD82 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN500108
发货至: 中国

Quick Overview for CD82 抗体 (C-Term) (ABIN500108)

抗原

See all CD82 抗体
CD82

适用

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人, 小鼠, 大鼠

宿主

  • 62
  • 26

克隆类型

  • 60
  • 28
多克隆

标记

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  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This CD82 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

    • 15
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
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    • 1
    • 1
    C-Term

    特异性

    This antibody detects CD82 at C-term.

    交叉反应 (详细)

    Species reactivity (tested):Human, Mouse

    纯化方法

    Peptide affinity chromatography

    免疫原

    KAI1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human KAI1.

    亚型

    IgG
  • 应用备注

    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • 抗原

    CD82

    别名

    CD82

    背景

    KAI1 was initially identified from a T-cell activation study as a four-transmembrane protein that plays an accessory role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is ubiquitously expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. Recently, KAI1 was found to interact with DARC, the Duffy antigen for chemokines using a yeast two hybrid screen. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least two isoforms of KAI1 are known to exist.Synonyms: C33 antigen, IA4, Inducible membrane protein R2, KAI1, Kangai-1, Metastasis suppressor Kangai-1, SAR2, ST6, Suppressor of tumorigenicity protein 6, TSPAN27, Tetraspanin-27

    基因ID

    3732

    NCBI登录号

    NP_002222

    UniProt

    P27701

    途径

    p53 Pathway
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