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IRAK2 抗体 (C-Term)

IRAK2 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN500038
发货至: 中国
  • 抗原 See all IRAK2 抗体
    IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))
    抗原表位
    • 18
    • 15
    • 8
    • 8
    • 8
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 86
    • 11
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 87
    • 3
    克隆类型
    • 78
    • 12
    多克隆
    标记
    • 39
    • 8
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK2 antibody is un-conjugated
    应用范围
    • 65
    • 48
    • 23
    • 14
    • 14
    • 12
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    IRAK2 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy-terminus of mouse IRAK2a which is common to all four isoforms. mIRAK2 antibody will also recognize human IRAK2. Anti-IRAK2 has no cross response to IRAK. Anti-IRAK2 will also recognize human IRAK2.
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    Human IRAK2 (C-Terminus) Peptide
    亚型
    IgG
    Top Product
    Discover our top product IRAK2 Primary Antibody
  • 应用备注
    ELISA. Western Blot: 0.5 - 1 μg/mL. A 65 kDa band should be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    IRAK2 (Interleukin-1 Receptor-Associated Kinase 2 (IRAK2))
    别名
    IRAK2 (IRAK2 产品)
    别名
    IRAK-2 antibody, 6330415L08Rik antibody, AI649099 antibody, interleukin 1 receptor associated kinase 2 antibody, interleukin-1 receptor-associated kinase 2 antibody, IRAK2 antibody, Irak2 antibody
    背景
    The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation (2,3). Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion (4). IRAK2 is expressed in a variety of tissues.Synonyms: IRAK-2, Interleukin-1 receptor-associated kinase-like 2
    基因ID
    108960
    UniProt
    Q8CFA1
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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