HAP1 抗体 (Center)
Quick Overview for HAP1 抗体 (Center) (ABIN499942)
抗原
See all HAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody reacts to HAP1.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- HAP1 antibody was raised against a 19 amino acid peptide from near the center of human HAP1.
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亚型
- IgG
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anti-Huntingtin Associated Protein 1 (HAP1) (Internal Region) antibody
Verified HAP1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 132-328) antibodyHAP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 328-580) antibodyHAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (C-Term) antibodyVerified HAP1 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 160-381) antibodyHAP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 349-584) antibodyHAP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) antibodyHAP1 适用: 大鼠 WB, IHC, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated
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应用备注
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ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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别名
- HAP1
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背景
- Huntington\'s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening, the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1
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基因ID
- 9001
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UniProt
- P54257
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途径
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
抗原
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