GP6 抗体 (C-Term)
Quick Overview for GP6 抗体 (C-Term) (ABIN499916)
抗原
See all GP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to GPVI.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
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亚型
- IgG
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anti-Glycoprotein VI (Platelet) (GP6) (AA 86-231) antibody
GP6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 115-265) antibodyGP6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 309-337), (C-Term) antibodyGP6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22884 unconjugated
anti-Glycoprotein VI (Platelet) (GP6) antibodyGP6 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
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应用备注
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ELISA. Western Blot: 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- GP6 (Glycoprotein VI (Platelet) (GP6))
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别名
- Platelet Glycoprotein VI
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背景
- Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.Synonyms: GP6, GPVI, Glycoprotein 6
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基因ID
- 51206
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NCBI登录号
- NP_057447
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UniProt
- Q9HCN6
抗原
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