FLASH 抗体 (C-Term)
Quick Overview for FLASH 抗体 (C-Term) (ABIN499842)
抗原
See all FLASH (CASP8AP2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- FLASH antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human FLASH (C-Terminus) Peptide
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亚型
- IgG
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anti-CASP8 Associated Protein 2 (CASP8AP2) antibody
CASP8AP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (AA 110-159) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (AA 1733-1982) antibodyCASP8AP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (N-Term) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-CASP8 Associated Protein 2 (CASP8AP2) (N-Term) antibodyCASP8AP2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: 0.25 to 0.5 μg/mL. An approximate 220 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
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别名
- CASP8AP2 / FLASH
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背景
- A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed.Synonyms: CASP8-associated protein 2, KIAA1315, RIP25
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基因ID
- 9994
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UniProt
- Q9Y563
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途径
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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