FGF4 抗体 (C-Term)
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Quick Overview for FGF4 抗体 (C-Term) (ABIN499836)
抗原
See all FGF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to FGF4.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- FGF4 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human FGF4.
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亚型
- IgG
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应用备注
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ELISA. Western Blot: 0.5 - 1 μg/mLImmunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- FGF4 (Fibroblast Growth Factor 4 (FGF4))
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别名
- FGF4
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背景
- Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.Synonyms: Fibroblast growth factor 4, HST, HST-1, HSTF1, Heparin secretory-transforming protein, Heparin-binding growth factor 4, KS3, Transforming protein KS3
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基因ID
- 2249
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UniProt
- P08620
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance
抗原
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