UBQLN4 抗体 (N-Term)
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北京 101111
Quick Overview for UBQLN4 抗体 (N-Term) (ABIN499635)
抗原
See all UBQLN4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody reacts to CIP75.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.
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亚型
- IgG
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anti-Ubiquilin 4 (UBQLN4) (AA 300-390) antibody
UBQLN4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 4 (UBQLN4) (AA 287-336) antibodyUBQLN4 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 犬, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 4 (UBQLN4) (Middle Region) antibodyUBQLN4 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 豚鼠, 斑马鱼, 犬, Pig, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 4 (UBQLN4) (AA 201-250) antibodyUBQLN4 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: CIP75 antibody can be used for detection of CIP75 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- UBQLN4 (Ubiquilin 4 (UBQLN4))
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别名
- Ubiquilin-4
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背景
- The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.Synonyms: A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, CIP75, Connexin43-interacting protein of 75 kDa, UBIN, UBQLN4
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基因ID
- 56893
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UniProt
- Q9NRR5
抗原
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