CCDC98 抗体 (N-Term)
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- 抗原 See all CCDC98 (FAM175A) 抗体
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CCDC98 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody reacts to CCDC98.
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
- 亚型
- IgG
- Top Product
- Discover our top product FAM175A Primary Antibody
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anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 51-150) antibody
FAM175A 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 1-313) antibodyFAM175A 适用: 人 WB, IP, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal ABRA1-01 unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 1-313) antibodyFAM175A 适用: 人 WB, IP, FACS 宿主: 小鼠 Monoclonal ABRA1-01 unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 350-400) antibodyFAM175A 适用: 人 WB, IP, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
- 别名
- CCDC98 (FAM175A 产品)
- 别名
- CCDC98 antibody, abra1 antibody, ccdc98 antibody, fam175a antibody, ABRA1 antibody, 3830405G04Rik antibody, 5630400M01Rik antibody, AI506069 antibody, AL024423 antibody, AV118690 antibody, Ccdc98 antibody, RGD1305287 antibody, zgc:103522 antibody, abraxas 1, BRCA1 A complex subunit antibody, Coiled-coil domain-containing protein 98 antibody, BRCA1 A complex subunit antibody, family with sequence similarity 175 member A antibody, abraxas 2a, BRISC complex subunit antibody, abraxas 1, BRCA1 A complex subunit S homeolog antibody, ABRAXAS1 antibody, abraxas1 antibody, Abraxas1 antibody, FAM175A antibody, abraxas2a antibody, abraxas1.S antibody
- 背景
- CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A
- 基因ID
- 84142
- NCBI登录号
- NP_620775
- UniProt
- Q6UWZ7
- 途径
- DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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