BRSK1 抗体 (Center)
Our Local Distributor
北京 101111
Quick Overview for BRSK1 抗体 (Center) (ABIN499501)
抗原
See all BRSK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Center
-
特异性
- This antibody reacts to BRSK1.
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- BRSK1 antibody was raised against a 28 amino acid peptide from near the center of human BRSK1.
-
亚型
- IgG
-
-
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 310-510) antibody
BRSK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 426-591) antibodyBRSK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 355-384) antibodyBRSK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40234 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (Internal Region) antibodyBRSK1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 654-684), (C-Term) antibodyBRSK1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5415 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (C-Term) antibodyBRSK1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
ELISA. Western Blot: BRSK1 antibody can be used for detection of BRSK1 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C.
-
-
- BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
-
别名
- BRSK1
-
背景
- BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.Synonyms: BR serine/threonine-protein kinase 1, KIAA1811, SAD-B, SAD1, SAD1 kinase, Serine/threonine kinase SAD-B
-
基因ID
- 84446
-
UniProt
- Q8TDC3
抗原
-
