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PRDM1 抗体 (C-Term)

This anti-PRDM1 antibody is a 兔 多克隆 antibody detecting PRDM1 in WB, IF 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN499475
发货至: 中国

Quick Overview for PRDM1 抗体 (C-Term) (ABIN499475)

抗原

See all PRDM1 抗体
PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

适用

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人, 小鼠, 大鼠

宿主

  • 42
  • 24
  • 3
  • 1

克隆类型

  • 47
  • 23
多克隆

标记

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  • 1
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This PRDM1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • 抗原表位

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    • 3
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    • 2
    • 2
    • 2
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    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
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    • 1
    C-Term

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    Blimp-1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Blimp-1.

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: Blimp-1 antibody can be used for detection of Blimp-1 at 0.5 - 1 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C.
  • 抗原

    PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

    别名

    PRDM1 / BLIMP1

    背景

    Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells. Together with X-box-binding protein 1 (XBP1), Blimp-1 is induced upon terminal differentiation of plasma cells. The transcriptional repressor activity of Blimp-1 has also been found to regulate T cell homeostasis and function, possibly by suppressing the expression of the cytokines IL-2 and interferon-gamma during T cell development. More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to show the expected migration, proliferation, and repression of homeobox genes that normally accompany specification of primordial germ cells.Synonyms: BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1, PRDI-binding factor 1, Positive regulatory domain I-binding factor 1

    基因ID

    639

    NCBI登录号

    NP_001189

    UniProt

    O75626

    途径

    Regulation of Muscle Cell Differentiation
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