BICD2 抗体 (C-Term)
Quick Overview for BICD2 抗体 (C-Term) (ABIN499457)
抗原
See all BICD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to BICD2. It will not cross-react with BICD1.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- BICD2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human BICD2.
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亚型
- IgG
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anti-Bicaudal D Homolog 2 (BICD2) (AA 511-625) antibody
BICD2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bicaudal D Homolog 2 (BICD2) (AA 440-620) antibodyBICD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bicaudal D Homolog 2 (BICD2) (AA 787-818), (C-Term) antibodyBICD2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15418 unconjugated
anti-Bicaudal D Homolog 2 (BICD2) (C-Term) antibodyBICD2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- BICD2 (Bicaudal D Homolog 2 (BICD2))
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别名
- BICD2
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背景
- BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2
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基因ID
- 23299
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UniProt
- Q8TD16
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途径
- Maintenance of Protein Location
抗原
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