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BACE2 抗体 (C-Term)

This anti-BACE2 antibody is a 兔 多克隆 antibody detecting BACE2 in WB, IHC (p) 和 EIA. Suitable for 人.
产品编号 ABIN499397
发货至: 中国

Quick Overview for BACE2 抗体 (C-Term) (ABIN499397)

抗原

See all BACE2 抗体
BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

适用

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宿主

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克隆类型

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多克隆

标记

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This BACE2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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    C-Term

    特异性

    BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    Human BACE2 (C-Terminus) Peptide

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: BACE2 antibody can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C.
  • 抗原

    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

    别名

    BACE2

    背景

    Accumulation of the amyloid-beta (alphabetaβ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1

    基因ID

    25825

    UniProt

    Q9Y5Z0
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