APH1A 抗体 (N-Term)
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北京 101111
Quick Overview for APH1A 抗体 (N-Term) (ABIN499307)
抗原
See all APH1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody reacts to APH1a.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- APH1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human APH1a.
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亚型
- IgG
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anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 71-170) antibody
APH1A 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (Internal Region) antibodyVerified APH1A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (C-Term) antibodyAPH1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 90-118) antibodyAPH1A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (N-Term) antibodyAPH1A 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 80-130) antibodyAPH1A 适用: 人, Cow, 犬, 马, 猴, Opossum WB 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 77-109), (N-Term) antibodyAPH1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4994 unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (Middle Region) antibodyAPH1A 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: APH1 antibody can be used for detection of APH1 at 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
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别名
- APH1A
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背景
- APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the γsecretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma and epsilon sites and can lead to the accumulation of the Amyloid beta peptide A beta cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1alpha as the principal isoform present in the gamma secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE.Synonyms: APH-1A, Aph-1 alpha, CGI-78, Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor
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基因ID
- 51107
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UniProt
- Q96BI3
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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