AES 抗体 (C-Term, N-Term)
Quick Overview for AES 抗体 (C-Term, N-Term) (ABIN499225)
抗原
See all AES 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term, N-Term
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特异性
- AES antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human AES.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Human AES / Amino-terminal enhancer of split / GRG / ESP1 / TLE5 (C-Terminus) Peptide
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亚型
- IgG
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anti-Amino-terminal Enhancer of Split (AES) (AA 1-264), (N-Term) antibody
AES 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibodyVerified AES 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibodyAES 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibodyAES 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (N-Term) antibodyAES 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 143-192) antibodyAES 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 非洲爪蟾, 斑马鱼, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (AA 1-264) antibodyAES 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Amino-terminal Enhancer of Split (AES) (C-Term) antibodyAES 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western Blot: AES antibody can be used for the detection of AES at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- AES (Amino-terminal Enhancer of Split (AES))
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别名
- AES / ESP1
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背景
- Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (2,3). AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis (4). It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. (4). Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (4).Synonyms: AES1, Amino-terminal enhancer of split, GRG protein, Gp130-associated protein GAM
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基因ID
- 166
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NCBI登录号
- NP_001121
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UniProt
- Q08117
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途径
- WNT signaling, SARS-CoV-2 Protein Interactome
抗原
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