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ACE2 抗体 (C-Term)

The 兔 多克隆 anti-ACE2 antibody (ABIN499191) specifically detects ACE2 in WB, IHC (p) 和 EIA. The antibody is reactive with 人 samples.
产品编号 ABIN499191
发货至: 中国
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Room 801-803
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Quick Overview for ACE2 抗体 (C-Term) (ABIN499191)

抗原

See all ACE2 抗体
ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

适用

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宿主

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克隆类型

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多克隆

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This ACE2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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    C-Term

    特异性

    ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2. Anti-ACE2 has no cross response to ACE1.

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    Human ACE2 (C-Terminus) Peptide

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: ACE2 antibody can be used for the detection of ACE2 at 0.5 to 2 μg/mL. A 90 kDa band can be detected. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C.
  • 抗原

    ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

    别名

    ACE2

    背景

    Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function (4).Synonyms: ACE-related carboxypeptidase, Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog

    基因ID

    59272

    NCBI登录号

    NP_068576

    UniProt

    Q9BYF1

    途径

    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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